Research 2017-06-19T14:59:01+00:00

Research

The peripheral auditory system is a marvel of engineering, able to detect vibrations that occur at the molecular level, while also capable of detecting motion ten orders of magnitude greater without damaging the sensory cells.

Aside from this incredible dynamic range, the auditory system operates across 4 orders of magnitude in frequency. In accomplishing these amazing feats, a single set of sensory hair cells are used. These cells must survive for an entire lifespan.

Damage to these cells results in permanent hearing loss. Damage can occur from noise exposure, from toxic compounds, from genetic disorders and simply from normal wear and tear that accrues with aging.

The Ricci lab is interested in unraveling the molecular mechanisms of audition and in so doing identifying sites of intervention for the protection, preservation and restoration of hearing. To do this we use multiple novel technologies to explore the initial stages of the hearing process.

Our Goal

Identify the biophysical and molecular mechanisms most relevant to how sound information is processed and conveyed to the brain.

Develop technologies and therapies that will prevent, repair or replace damage to the inner ear that would result in hearing loss.

Three Areas of Research

Mechanotransduction

Likely the most primitive sense used by all cells at some level. The inner ear has specialized this sense to operate at molecular dimensions across more than 4 orders of magnitude in frequency. The hair bundle of the sensory cell is the site of mechanotransduction. Here an unidentified ion channel responds to force exerted when the the hair bundle is deflected. The sensitivity in time and force are unmatched by any known mechanosensitive process. The dynamic range of hair cell mechanotransduction is dictated by an adaptation process.

Ongoing Projects

Synaptic Transmission

Each fiber innervating a hair cell makes one synaptic contact and this contact is responsible for conveying information about the frequency, intensity and timing of the hair cell response (1). These synapses and afferent fibers vary in their sensitivity and dynamic range (2) despite the only input being from a single hair cell with a uniform receptor potential. These synapses are also unique in being able to operate at high rates for extended periods of time without fatigue (3).

Ongoing Projects

Translational Research

The number of people with hearing loss are reaching epidemic levels largely due to an aging population and the increased exposure to long durations and high levels of sound. Finding ways to prevent, repair and restore hearing is the ultimate goal of all of our research. The cochlea remains a major technical challenge for both diagnosis and treatment.  Our approach to translational research comes at multiple levels:

  1. Designing nonototoxic aminoglycoside antibiotics. The goal is to prevent these compounds from passing through the MET channel which will prevent uptake thereby preventing hair cell loss.
  2. We are testing the hypothesis that age related hearing loss begins with loss of high threshold using whole animal physiological techniques.
  3. We are developing technology for monitoring function in vivo.
  4. We are developing technology for in vivo drug delivery.