The number of people with hearing loss are reaching epidemic levels largely due to an aging population and the increased exposure to long durations and high levels of sound. Finding ways to prevent, repair and restore hearing is the ultimate goal of all of our research. The cochlea remains a major technical challenge for both diagnosis and treatment. Our approach to translational research comes at multiple levels:
- Designing nonototoxic aminoglycoside antibiotics. The goal is to prevent these compounds from passing through the MET channel which will prevent uptake thereby preventing hair cell loss.
- We are testing the hypothesis that age related hearing loss begins with loss of high threshold using whole animal physiological techniques.
- We are developing technology for monitoring function in vivo.
- We are developing technology for in vivo drug delivery.