PIP2 is a lipid known to interact with many ion channels including a range of mechanically sensitive ion channels. Does PIP2 directly interact with hair cell mechanotransduction machinery?
PIP2 is enriched at the tops of stereocilia, right near to the site of mechanotransduction. We know that PIP2 can alter MET channel properties such as single channel conductance and ion permeation. We also know that it is required for fast adaptation. We are presently trying to identify the interacting molecules of PIP2 to unravel toe specific molecular mechanisms of these processes.