Project Description

Imaging of aminoglycoside uptake

How do aminoglycosides move into the cochlea? How do we block ototoxicity induced by aminoglycosides?

Aminoglycoside is antibiotics used to treat gram-negative bacterial infections. This drug saves people from life-threatening infection. However, it has side effects which are ototoxicity and nephrotoxicity. Even though nephrotoxicity is reversible, ototoxicity is permanent. The ototoxicity occurs in as many as 20% of patients who received aminoglycoside intravenously for multiple days. Our goal of this study is to determine aminoglycoside trafficking route into cochlea by in vivo monitoring of aminoglycoside and investigate a blocking strategy of it.