I have been taking a profound interest in imaging in neuroscience fields. During my Ph.D. training, I was involved in developing and optimizing synchrotron X-ray tomography systems and micro/nano imaging researches based on quantitative analysis of the 3-D microstructures of brain. Because my PhD training mainly focused on the technology itself, my interest evolved into how to use such technologies to solve biological questions in neuroscience fields. This brought me to Stanford.
My first project at Stanford was to determine the mechanisms of cochlear trauma after blast injury. I studied cochlear damage pathways using a combination of techniques. These included not only 3D cochlear imaging in vivo using optical coherence tomography, but also more routine approaches such as cochlear electro-physiology and immunohistochemistry. This research is important because it strives to understand the fundamental mechanisms of hearing loss.
Now, I am focusing on in vivo imaging of calcium or voltage changes in the cochlea based on combination of two-photon microscopic system and fluorescent sensors. In vivo imaging of cochlea is challenging because cochlea is covered with bone and filled with fluids. My final goal is to determine receptive field properties of cochlea.